Wellbutrin (bupropion)

Wellbutrin, also known as bupropion, is a medication primarily used to treat depression and seasonal affective disorder in adults. Classified as an antidepressant, it’s designed to help balance certain chemicals in the brain that affect mood. Approved by the Food and Drug Administration (FDA) in 1985, Wellbutrin has gained recognition for its efficacy in addressing these mental health conditions. Notably, it also holds FDA approval for aiding smoking cessation, broadening its therapeutic applications.

* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Wellbutrin (bupropion).Bupropion is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation).

Wellbutrin (bupropion)

Wellbutrin (bupropion)

Depressed mood – feeling sad, empty, or tearful.

Wellbutrin stands as a valuable option in the treatment toolkit for depression and seasonal affective disorder, with additional benefits in smoking cessation. Its off-label uses have shown promise in effectively managing symptoms of other mental health conditions, such as anxiety.

Before taking this medicine

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not take this medicine if you are allergic to it or if you have ever had:

a seizure disorder;
an eating disorder such as anorexia or bulimia; or
if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not take this medicine to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking or for weight management.

Tell your doctor about all of your medical conditions and the drugs you use.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a head injury, seizures, or brain or spinal cord tumor;
narrow-angle glaucoma;
heart disease, high blood pressure, or a heart attack;
diabetes;
kidney or liver disease (especially cirrhosis);
depression, bipolar disorder or other mental illness; or
if you drink alcohol.

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